No, Sasuke is yet to die in Boruto. However, there are speculations that he might die in the future. After all, we did see Boruto fighting Kawaki using Sasuke's sword and wearing his cloak and headband in the series prologue. That's definitely supposed to mean something! Will Sakura die in Boruto? First of all, she won't die. Second of all, the suggestion that a female character has to *die* to satisfy your need for pointless drama and that Sasuke has to go through another tragedy and another dose of manpain to “prove” his love is laughable and makes me wonder how old you are.
Did Sasuke die in Boruto?
No, Sasuke does not die in Boruto. He lost his Rinnegan in the climactic battle against Isshiki and Momoshiki, but Sasuke held on to his life. It does not seem at this point another conflict could take his life. Boruto used his newfound Karma abilities to transport the group away from Konoha.
Did Sasuke lose his rinnegan? Not only did Naruto lose Kurama after the two of them had activated Baryon Mode to help keep up with the Otsutsuki, but Sasuke suddenly loss his Rinnegan when Momoshiki (who had awakened within Boruto's body after the fight) caught him by surprise and stabbed it out.
Will Sarada die in Boruto?
It is implied in the first episode of Boruto that every shinobi but Boruto dies. So if we assume that this is true, then yes: she dies. However, given the nature of the anime, I think there will be some sort of plot-twist that will allow for more characters to survive. Did Kakashi die? When the Akatsuki leader, Pain, invades Konoha, Kakashi engages him in battle, and dies from exhausting all his energy. However, after his confrontation with Naruto, Pain decides to use all of his remaining power to revive all those killed in the battle at Konoha, including Kakashi.
Do Sakura die?
After falling asleep one day, Sarada dreamt of a war going on around her, and Sakura was killed before her eyes. Of course, the dream ended with Sarada waking in a panic, and she was relieved to know her mom was alright. Did Naruto get Sharingan? He was given a Sharingan and the genetic material of Hashirama Senju by Orochimaru, and he became obsessed with the Uchiha Clan - which is why he took the Uchiha name. He somehow forged a Mangekyo Sharingan for himself and was able to hold his own against admittedly weakened Naruto and Sasuke in Boruto.
Will Boruto become like Itachi?
In short, there is no equivaltent to Itachi in Boruto.. Will Naruto become stronger after losing Kurama? After losing Kurama, Naruto needs to train in the Sage Mode arts once again and by doing so, improve its usage. An improved Sage Mode could help him get much stronger and possibly even take on an Otsutsuki once again, despite not having the power of Kurama anymore.